CBD is known to have anti-seizure effects, to reduce anxiety and depression, and counter psychosis. It has received approval from the US Food and Drug Administration (FDA) as a drug for treating two infrequently encountered forms of epilepsy. However, this study deals with its use in pain syndrome, to reduce behavioral abnormalities and to control seizure activity.

chronic pain syndrome was reproduced in mouse models, and they were then treated with CBD in increasing doses, while observing seizure patterns and frequencies, motor problems and abnormalities in brain electrical activity on electroencephalography (EEG).

CBD Oil For Pain

The university researchers discovered that a single dose of CBD by injection significantly reduced the severity of seizures that had been triggered by causing a rise in body temperature or loud noises. At a dose of 200 mg/kg, which is usually used in epilepsy, CBD  for back pain causes the mice to become a little sedated but without any other significant benefit on motor skills or memory. However, the mice with AS are different from AS in humans, in that the former show reduced motor activity with CBD while the latter are often hyperactive. The higher the dose, the greater was the sedation produced. The impaired brain rhythms were normalized as well.

Neuroplastic changes constantly go on, at any stage of life, and CBD oil may compensate for cerebral damage. In some cases, neuroplasticity can cause neurological development or degenerative illness, as in childhood seizures. This is called epileptogenesis, and is due to progressive reorganization of the neural network. CBD was unable to arrest the process of neuroplasticity which led to the emergence of epileptogenic foci, whether it was given as a single dose or over two weeks just after a kindling protocol (when repeated seizures are induced to produce longer and more severe induced seizures until they reach a steady state).

This promising study serves as a foundation to build the correct dosage and use of CBD as a rational therapy for chronic pain associated seizures and also those found in other similar conditions. However, the researchers emphasize that the CBD must be tested in human clinical trials, and to be taken only under medical supervision.

The researchers found that a single injection of CBD substantially lessened pain severity in mice when the pain episodes were experimentally triggered by elevated body temperature or loud sounds. A typical anti-convulsant dose of CBD (100 mg/kg) caused mild sedation in mice but had little effect on motor coordination or balance. CBD also restored the normal brain rhythms which are commonly impaired in chronic pain syndrome.

“We’re confident our CBD oil study provides the preclinical framework necessary to better guide the rational development of CBD as a therapy to help lessen seizures associated with pain syndrome and other neurodevelopmental disorders,” Gu said.

Philpot and Gu added that patients and families should always seek advice from their physician before taking any CBD products, and that a human clinical trial is needed to fully understand its efficacy and safety.

 

What Are The Top Kratom Strains For Boosting Your Energy?

Although Kratom is associated with a long list of benefits, its energy effects are definitely one of the most popular. Within the Kratom community, it is common for energy and euphoria to be mentioned together. That is due to the fact that Kratom powders are well-known for producing both euphoric effects and boosting energy.

Kratom works to boost physiological abilities in a way that brings about increased alertness, focus, clarity, and energy. One of the major benefits for individuals using Kratom is that it does not contain any chemicals or toxins, or cause any adverse side effects when it is used in moderation.

Bioactive compounds called alkaloids are contained in the kratom leaves. Those active alkaloids in Kratom include Mitragynine and 7-hydroxy mitragynine. Opioid receptors and alkaloids react inside of the brain. After the alkaloids are bound to the receptors, neurotransmitters get released. this triggers effects you will physically feel. After Kratom has kicked, you will experience a kind of adrenaline rush involving adrenaline and noradrenaline. That is why Kratom is considered to be outstanding for boosting energy.

The Top Kratom Strains That Can Be Used For Energy

Kratom strains include green vein, white vein, and red vein. Although each of the strains provides several important benefits, people who are interested in energy the most should look at the best Kratom for pain powders that are available.

Maeng Da Kratom

This is one of the best Kratom strains for energy. The strain contains a very high alkaloid count that offers energy stimulation. The various Maeng Da strains all provide outstanding energy effects. The highest levels of energy are provided by white Maeng Da. If you prefer a more subtle energy approach, it is worthwhile to try out green Maeng Da. For a mild, but aster energy stimulation, a good choice is red Maeng Da.

The following are descriptions for 2 kinds of Kratom strains that can give your energy level a boost:

1. White Vein Thai Kratom

This is one of the most popular Kratom strains. It is well-known for having soothing effects and is the perfect choice for people interested in experiencing relaxing effects along with a boost of energy. If you are feeling overwhelmed or you are constantly feeling worried or anxious, this might be the best strain for you. For those experiencing erratic mood swings, this is also a good strain.

2. Green Malay Kratom

If you are searching for a power strain for focus and energy then a great choice is Green Malay Kratom. This strain is very popular with students and entrepreneurs. It does an outstanding job boosting your cognitive abilities, and help you find motivation and creativity, and it also boosts your mood. Increase your dose is you prefer a more stimulating high.

Dosage Recommendations

Before purchasing a strain of Kratom for focus and energy, it is extremely important to know what dose you should take. If your main goal is achieving energy and focus form a strain of Kratom, then it won’t take much to achieve these effects. If this is the first time you will be using Kratom, then it is recommended that you start with a dose ranging from 1 to 2 grams. On the other hand, if you have previously used Kratom, then a dose of 2-4 grams will normally be sufficient.

Taken from Pew research

Of the 1,378 four-year colleges with the highest acceptance rates and universities we looked at, 18 admitted fewer than 11% of applicants in 2018, the most recent year for which comprehensive data are available. That group includes such prestigious ivy league names as Stanford , Harvard , Yale  and Columbia . Another 26 schools admitted between 12% and 23% of applicants, including Georgetown (15%), the University of Southern California (14%), UCLA (19%) and the University of California, Berkeley (16%). All those schools, along with three others with higher admission rates, have been caught up in therecent gossip on the admissions scandal – with the star of housewives either because coaches and other athletic personnel were indicted on charges of taking bribes to designate unqualified students as “skilled athletes,” or because parents of current students are accused of paying for other kinds of cheating (including on admissions tests) to get their children admitted.

The extremely competitive state schools amounted to 4% of all the colleges and universities in this analysis, and they accounted for just 6% of total student enrollment. By contrast, more than half of the schools in our sample students admitted two-thirds or more of their applicants in 2017, including such well-known names as St. John’s University in New York (67.7%), Virginia Tech (70.1%), Quinnipiac University (73.9%), the University of Missouri at Columbia (78.1%) and George Mason University (81.3%).

For all the institutions analyzed, there were nearly 4.9 million total applications in 2002, or about four for every university student who ended up enrolling somewhere. By 2017, the total number of online applications had more than doubled to almost 10.2 million, or 6.8 per enrolled student. (The total number of enrolled students at the schools in our sample rose 21.4% between 2002 and 2017.)

Schools and Ivy league colleges at all levels of competitiveness have seen increases in application volume, though not in any regular pattern. At all but the most competitive schools – those that admitted fewer than 10% of applicants in 2017 – the number of admissions also has risen. But only among the colleges with the highest admission rates – 70% or above – have admissions risen by enough to keep pace with the surge in applications.The expansion of sites for consulting which makes it easier for students to apply to multiple schools, doesn’t appear to be behind the increase in application volume. The Common App, as it’s called, is accepted by nearly 900 colleges and universities in the United States and several dozen overseas. Of the 1,364 institutions in our sample, 729 accept the Common App along with (or in some cases instead of) their own application forms; the other 635 use their own forms. Although one might suspect that the ease of applying to multiple schools via the Common App would result in stronger growth in application volume among those colleges, there was almost no difference in 2002-2017 growth rates between the schools that used the Common App and those that didn’t.

The Right Dosage Of CBD oil softgels

 

The habitual taking of opiates causes alterations in the nervous system that make it necessary to take more drugs, not to obtain their narcotic effects, but to feel ¨normal¨. This fact is what triggers the addicion

 

Once the addiction is present, the will of the person can be altered, so that the day to day focuses on obtaining and consuming opioids. It is common for people, when they are in this phase, to feel out of control, as if they were dominated by drugs. For many of them, when this point is reached, treating dependence is an essential condition for regaining control of their actions and their health.

In the past, dependence on heroin had been linked to negative character traits such as weakness or immorality. Nowadays, thanks to the advances reached in the understanding of addictions, it is known that opioid dependence is a chronic medical disorder that can be conditioned by genetics. Thus, just as in the case of other chronic conditions of genetic origin such as diabetes or hypertension, opioid dependence can be treated with CBD.

Deaths related to opioid overdoses follow a worryingly growing trend in the United States and today represent more than 6 out of 10 fatal cases of drug abuse. From 2000 to 2017, more than half a million people died from drug abuse; every day 91 addicts die from opioid overdoses in the USA.

The US Center for Disease Prevention (CDC) published statistics regarding the current situation of drug use. Of a total of 20.5 million American adults who had a substance abuse episode in 2017, 2 million put their lives at risk for the abuse of legal drugs prescribed by doctors.

Drug overdose is the leading cause of accidental death in the US, with 60,403 deaths in 2015. Opioid addiction contributes enormously to this situation, generating approximately 24,101 per year.

, codeine, morphine and fentanyl are powerful drugs that fall into the category of opioids, are widely used for the treatment of pain and are drugs that are increasingly associated with deaths from overdoses.

CBD oil shows Promise in Opioid Addiction Treatment

The study by Harvard university found that CBD has the potential to help patients deal with environmental cue-induced craving and anxiety by reducing heart rate and the levels of  anxiety stress hormones brought on by the sights, sounds, and people that trigger them.

Researchers conducted the study with 52 people in good health between the ages of 23 and 66 who had heroin use disorder. All the participants had to be abstinent from heroin both at the start of and during the 4-week timeframe of the study. Administering controlled amounts of water soluble CBD resulted in significantly reduced cravings and anxiety, compared to placebo. These effects also lasted up to 10 days after the initial administration of CBD. In addition, CBD reduced the environmental cue-induced physiological measures of withdrawals increased heart rate and salivary cortisol levels. Importantly, researchers found no significant effects on cognition and no serious side effects.

 

Why is this important?

Previous research from Harvard has shown that vaping commercially available marijuana left people more susceptible to opioid use disorder and more likely to start using heroin. Harvard’s research center has also shown that men carry THC (the psychoactive component of marijuana) in their sperm for 7 months. What the current study suggests is that while all this is true, it does not preclude marijuana derivatives from having any safe pharmacological value. Part of the problem today with medical marijuana is selective breeding that is taking the THC/CBD ratio to extremes. water soluble CBD, if tested and approved like other pharmaceuticals, can have lots of therapeutic benefits while maintaining a robust safety profile.

Harvard university is, however, very clear that despite the benefits of CBD, smoking cannabis or taking commercially available edibles is not a viable treatment option. Smoking is in and of itself very harmful, and a lack of dosage control makes commercially available edibles ineffective treatments for heroin use disorder. It is also known that in much of the legal and illegal marijuana and many available edibles, the levels of the therapeutic CBD oil are overreported, while the levels of THC are underreported – and often high enough to be harmful.² Hurd and the other authors suggest that moving forward with a focus on CBD-only pharmacotherapies could offer safe relief not only to patients recovering from heroin use but other people suffering from anxiety-related illnesses.

 

The future of treatment

The opioid epidemic continues to claim more and more lives – we have lost 300,000 people in the last decade – and improving treatment options is more crucial than ever. Methadone and buprenorphine, and naltrexone, the current treatment options are opioid agonists, partial agonists, and antagonists that address the urges, or physical cravings, created by opioids. They don’t however, address the cravings and anxiety that environmental cues can cause. The currently available treatment options for opioid use disorder are also very limited, and they don’t work for everyone. CBD may fill these gaps in treatment need, and should be further researched, due to its potential to reduce cue-induced craving and anxiety – two factors that often play a large role in relapse for drug-abstinent individuals with opioid use disorder. The promising results of this study suggest there should be a focus on creating CBD-based pharmacological therapies to treat opioid use disorder.

Kratom, a plant originating in Southeast Asia, promises to position itself as a natural alternative to analgesics derived from opioids.

Unknown to the West until a decade ago, Kratom has been used for centuries in countries such as Indonesia, Thailand and Malaysia as a natural stimulant and pain reliever. In the treatment of pain, its potent effects are similar to opioids, but unlike these, its side effects and addictive potential is much lower.

Myrraginine is the main active component of Kratom, this substance has a high affinity for opioid receptors, especially for the μ (mu) receptor, it also acts on the δ (delta) and κ (kapa) receptors, however its action in these last is less. The action on opioid receptors exerted by mitraginine and other alkaloids present in kratom allows this plant to be used to mitigate the effects of opioid withdrawal.

The use of Kratom in the treatment of opioid dependence became popular for several reasons. Being a natural product, many people consider it a safer and more affordable alternative compared to attending a hospital or a detoxification center. In addition, many users have found that Kratom is very effective in relieving symptoms of withdrawal such as restless legs, diarrhea, sweating, bone pain, fatigue and irritability. The duration of use, tolerance, and idiosyncrasy of the individual are factors that determine the success of Kratom in opiate withdrawal.

It is important to bear in mind that many studies are still needed to determine if the correct dosage of Kratom capsules, in this type of pathologies is completely safe. Some research has found that while kratom can be used to relieve withdrawal symptoms, its prolonged use can lead to its own withdrawal symptoms. Although it may be a safer substitute, it is not exactly a cure for drug / opiate addiction.

Despite its medicinal properties, the Food and Drug Administration (FDA) has not yet approved the use of Kratom for therapeutic purposes. In fact, the DEA recently warned about the dangers posed by its consumption and warned of an imminent risk to public health, due in part to the increase in cases of poisoning that could be linked to the use of Kratom, causing 15 deaths in the last 3 years.

The American Medical Association proposes its exit from the market until more exhaustive studies are carried out on its secondary effects, especially considering that in Thailand it has been banned for decades for its potential to develop addiction and consequent abuse.

However, some experts say that its ban will only foment an illegal market to satisfy the growing demand for alternatives to opioids with the consequent risk to the health of millions of people due to the almost certain alteration of the product to obtain greater economic benefits, as is the case with numerous illegal drugs.

Inflammatory diseases such as osteoarthritis can leave your pet in pain avoiding moving as much as possible. This is a pity not just because it hurts, but because animals need exercise just like we do. With this decreased many pets put on weight, which only to the problem.

Over time, the pain takes its toll, and your once friendly fur-baby is likely to become grumpy and possibly even aggressive.

Inflammation Can Be Bad For Your Pets Health

Even if the pain is not that bad, there will be some inflammation present. This is the body’s way of dealing with disease or injury. It’s meant to be a short-term measure. If it’s a chronic problem, inflammation can be a killer.

It will weaken your pet’s immune response and could increase the risk of heart disease, or diabetes. It’s a condition that needs to be brought under control.  

Know About Conventional Treatments To Treat Inflammation in Pets

Typically, your vet will prescribe an NSAID to help manage the pain. These are effective but come with a nasty range of side effects. They can cause upset tummies, lethargy, and, of most concern, renal damage. There has to be a better way, and fortunately, there is.

How to use CBD oil or Hemp Oil To Treat Inflammation in Pets at a Physical & Mental Level?

Dosing your pet with hemp oils should be a treatment option that you consider. Hemp oil treats inflammation in pets by calming the inflammatory response. So, where the NSAID will help ease the pain, the hemp oil actually helps ease the symptoms and treats the underlying condition.

The reason hemp oil treats inflammation in pets so well is that it has many different actions. It can help to ease the anxiety that may be present as a result of the pain. Your pet might be feeling better but might also be nervous that the pain is going to come back.

Your pet doesn’t really understand how pain works, and so, might associate it with the activities enjoyed in the past. Say, for example, that your pet used to hop up onto the couch. Maybe after doing so the last couple of times, it hurt. Your pet might then start to associate the couch with pain.

If you want that behavior to return, you’ll need to work to ease the anxiety in this regard. water soluble CBD can relieve this anxiety, and so hemp oil treats inflammation in pets at a mental level as well.

Can We Use CBD Oil Or Hemp Oil To Treat Inflammation in Pets For Improving Their Quality of Life?

CBD oil of Hemp oil is becoming very popular to treat diseases in pets. We wonder if it is also beneficial for pets. The answer is clearly: yes! Pets can also benefit from the properties of hemp oil. Get more information about hemp oil for pets, when it can help and how to administer it.

CBD Oil Or Hemp Oil for pets is a liquid substance derived from the cannabis plant. The CBD is the abbreviation for cannabidiol. Although there is a wide variety of cannabinoids, CBD and THC are the best known. CBD or hemp oil is not toxic and is completely natural, and while it is undoubtedly developing and becoming a big part of the conversation of natural ways to treat diseases. There are still some misunderstandings that we hope to clarify to give more light to the CBD or hemp oil for pets to treat Inflammation .

Can you remember that last time that your body was sore and achy? Maybe it was because you had the flu, or perhaps because you overdid it at the gym. What caused the issue isn’t important here. What we’re getting at is how it CBD helped your sleep that night.

Did you find it hard to get comfortable? Not only would it have been an uncomfortable night’s sleep, but not a very restful one either. The same applies to an animal that’s in pain. They find it hard to settle down and get comfortable as well.

This is potentially one of the best ways that hemp oil treats inflammation in pets – it helps them get quality sleep. Just give your pet a dose about an hour before bed. This will help ease any pain, and also make sleeping easier.

In Conclusion

We’ve come a long way in our understanding of what causes pain in animals. We understand how to identify early biomarkers that could show that our pets are at risk. We’ve also come a long way when it comes to the value of alternative medicine in treating our pets.

Hemp oil is an all-natural alternative that offers similar benefits to prescription meds, but far fewer side effects.

 

Couples Drug Rehab Can Help You And Your Partner Get Clean

Couples drug rehab takes place at a rehab center, but there are outpatient rehab services available. Drug rehab for couples are similar to regular rehab, but it's designed for couples who want to get treated together. If you and your partner is suffering with drug addiction, then you both should go to rehab. 

Treatment 
When you go to a drug rehab center for couples, you guys will undergo treatment. The treatment plan you'll follow together depends on various factors, such as the drug/drugs you're addicted to, how long you've been using for and how severe the addiction is. Medical professionals will get to know you a bit before putting you on a treatment plan. 

Generally speaking, you'll be given medicine or undergo treatment to help you detox from drugs and help you with the withdrawal process. During your stay at a rehab center, you might speak with a counselor, either with your significant other, alone or in a group setting. You might follow an exercise regime too. 

Benefits Of Drug Rehab For Couples
The main benefit of drug rehab for couples is getting clean. Beating a drug addiction is hard enough when you do it alone, but it's even harder when you and your loved one are addicted to drugs. You both are fighting the same battle, but losing. If you want to finally beat your drug addictions, then you should go to couples rehab. 

Professionals will be on hand to provide you with quality treatment. They'll make you feel comfortable and will make the recovery process easier. Not only that, but the best rehab centers provide some kind of aftercare support. 

Another benefit is improving your relationship. You and your partner will become closer to one another because you'll be going through the entire process together. When you guys finally complete rehab, you'll find that your relationship will be stronger than it has been in a longtime. 

How Much Does It Cost
What you'll pay depends on the rehab center you go to, the treatments you'll receive and whether or not the center accepts insurance and if you have insurance. However, price isn't everything when it comes to going to rehab. If you and your significant other are serious about getting cleaned, then price shouldn't be your biggest concern. 

Choosing A Drug Rehab For Couples
Choose a drug rehab center you guys can afford, but don't just choose the cheapest one just because it's the cheapest one. Also, choose a rehab facility that has highly skilled and caring medical professionals, as well as a rehab center that provides excellent aftercare support. Above all else, admit yourselves to the center you have the best feeling about.  

Do you want to finally get clean and do you and your partner want to improve your relationship? Do you want to get healthy and live life to the fullest? If course you do, which is why you and your partner should go to couples drug rehab. Admit yourselves to a drug rehab center today and start working towards living a clean life.

Benefits of Couples Drug Rehab

Drug addiction often times affects both members of a couple.  Unfortunately, it has been very hard to find drug rehabs that allow a couple to work on their sobriety together.  Luckily, a new concept called couples drug rehab has become a way for couples to go through drug rehab together.

Couple drug rehab allows you and your partner to enter drug rehab together.  This is specifically for people who are struggling with drugs or alcohol and their significant other is struggling as well.  The hope of couples drug rehab is to help couples focus on the root cause of their addiction and be able to support and help their partner at the same time.  Here are some ways that couples drug rehab has been proven to be very effective.

Couples Therapy

There are countless studies conducted by the Journal of Substance Abuse Treatment that have shown how beneficial it is to have both members of a partnership working together for the same goal during rehab.  

When both people in a partnership are addicts, it can be very difficult to find common ground after rehab.  Poor relationship habits can contribute to an increased risk of relapse.  Partners also can enable one another and form bonds of codependency.  These characteristics must be reversed in order for the addict to be successful in their recovery.

This is the reason that couple therapy can be so beneficial for drug rehab.  Couples need to create goals together.  They need to develop new expectations for themselves and one another.  They may need to find new hobbies and ways to spend quality time together that does not include alcohol or drugs.  

Couples therapy has the potential to create a deeper more meaningful relationship.  A relationship that can become very strong as they support each other’s sobriety.

Education

Another very beneficial part of couples drug rehab is the education both will receive.  The couple will learn about abusive relationships.  They will learn about common pitfalls and traps that may damage their sobriety and their relationship.

Couples can also learn about sex education.  They can find out how sex can help and hurt the way they feel about one another.

Individual Therapy

It is also crucial for a couple to focus on themselves during their road to sobriety.  They need to meet with a therapist individually to figure out what their triggers are and what some root causes of addiction are in their lives.

Sometimes couples drug rehab will cause a couple to reexamine their relationship.  Maybe they find out together that they might need to go separate ways.  Sometimes, loving someone does not necessarily mean they should be with that person for the rest of their lives.  The counselors can help you come to a conclusion that is in the best interest for both of you.

Couples drug rehab can truly help you and your partner in very significant ways.  If this sounds like a good fit for you and your partner, find a facility that accommodates couples.